Comparative Evaluation of Gastric and Blood Anomalies in Coartem, Chloroquine, Fansidar and Linart and in Experimental Malaria
نویسنده
چکیده
Study on the effects of some antimalaria drugs; coartem, fansidar and lonart on gastric acid secretion was carried out for 14 days on thirty albino male and female mice infected with Plasmodium berghei berghei malaria parasite. The results showed that coartem at a dosage of 33.6mg/kg decreased red blood cells count as compared with control P<0.05, same with chloroquine at a dosage of 14.3mg/kg. But Lonart at a dosage of 32.1mg/kg increased red blood cells count (P<0.05) compared with control. In the white blood cells count, coartem increased its count (P<0.05) compared with control, similar effect but with slight increase was observed with fansidar. However, Lonart and chloroquine drugs have high significant increase in white blood cells counts as compared with control. Significant gastric acid output (P<0.05) was obtained with chloroquine administration same with lonart as compared with control whereas coartem and fansidar groups had reduced values as compared with control. All the mice infected with malaria parasites had elevated gastric acid output. It is concluded that both antimalaria drugs and malaria disease affect the gastric and blood physiology. Copyright © WJSRR, all rights reserved.
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